Avanafil is an oral medication and a PDE5 inhibitor. It is taken about 15 minutes before sexual intercourse. Do not take it more than once a day.
Do not use any PDE5 inhibitor if you are also taking nitrates to treat heart disease. Examples of nitrates include isosorbide mononitrate and nitroglycerin. Taking nitrates with avanafil can cause severe hypotension and even death.
Tadalafil is an oral medication that increases blood flow throughout the body. This PDE5 inhibitor can be taken at higher doses about 30 minutes before sexual intercourse and no more than once a day. It can also be taken at lower doses daily to be ready for intercourse and avoid having to plan ahead. Its effects can last up to 36 hours.
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